succinic acid pka

Nitric Acid - HNO. Succinic Acid CAS NO. If more than one picklist value is available per endpoint, results are displayed as concatenated distinct values, ordered by most to least commonly provided, with the % of provided values appended. Oxidation reduction potential in mV provides substance information on the substance’s oxidation reduction measured in millivolts at a temperature measured in °C. The availability of additional data beyond the five results displayed is indicated by (…) icon. The Agency thus cannot guarantee the correctness of the information displayed. By summarising the endpoint study data, ECHA aims to make this information accessible in a user-friendly way in line with the Agency’s goals and standards. For sections such as substance use, chemical properties and the classification and labelling of substances, the quantity and quality of the information is the responsibility of manufacturers and importers. Registrants can choose from the following (picklist) conclusions: Displayed is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as above. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Other names. Readily biodegradable but failing the 10-day window. See ‘Summary effect on fertility oral route’, except: This section displays the values related to neurotoxicity from all registered dossiers for the substance. Data for workers – eye exposure provides information on the substance’s hazard assessment conclusions regarding eye exposure (for workers). Data is generally standardised and displayed in milligram per litre or molar per litre. This section summarises the values related to short term toxicity to aquatic invertebrates from all registered dossiers for the substance. Regulatory process names gives the names under which the substance appears in ECHA's regulatory processes and lists. Examples include recommended measures on fire-fighting, transport, recycling and disposal. Processable data for study results is prioritised by endpoint conclusion: the most conservative value is displayed. This section summarises the flammability values from all registered dossiers for the substance. Note: Registrants can also select ‘other’ as the picklist conclusion. EC10 / LC10 or NOEC for marine sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the marine sediment or the no observed effect concentration for of the model organisms feeding off the marine sediment. This substance is used in the following products: pH regulators and water treatment products, anti-freeze products, metal surface treatment products, heat transfer fluids, hydraulic fluids and washing & cleaning products. This means that at pH 3.50, most succinic acid (83.9%) is present in its undissociated form; monodissociated succinate ion accounts only for approximately 16%, while the dissociation of the second carboxylic group is practically negligible (Usseglio-Tomasset, 1985). Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (in hours, longer prioritised over shorter). Registrants can choose the same picklist endpoint conclusions as mentioned under ‘Skin sensitisation’. The information is aggregated from REACH registered dossiers provided by industry through a use descriptor system based on five separate descriptor lists which in combination with each other form a brief description of use and exposure for certain life cycle stage. Registrants can choose from the following picklist endpoint conclusions/effect levels: Eye irritation provides substance information on the substance’s irritation effect on the eye. Long-term EC10 or LC10 or NOEC for birds provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the birds in the test, or the no observed effect concentration for birds. BOD5/COD ratio provides substance information on the substance’s BOD5/COD ratio values displayed in O2 (milli)gram per gram test material. The chemical is also known as “Spirit of Amber.” When it was first discovered, it was extracted from amber by pulverizing and distilling it using a sand bath. Data is generally displayed in milligrams per kilogram sediment (dry weight) or in milligram per litre. For example CLH index numbers, CN numbers, deleted CAS numbers, etc. The Candidate List includes substances that are subject to additional protocols and reporting obligations and which may eventually be included in the Authorisation list, further limiting their use. Displayed is the most conservative of the prioritised value(s). ECHA’s Guidance Chapter R.12: Use Descriptor system of ECHA’s Guidance on information requirements and chemical safety assessment, ECHA guidance chapter R.12: Use Descriptor system of ECHA Guidance on information requirements and chemical safety assessment, Guidance on the safe use of the substance, Endocrine disrupter testing in aquatic vertebrates – in vivo, Active/Inactive (pending). 2 Registrants can register their substance explosiveness as: Explosiveness. At least one notifier has indicated that an impurity or an additive present in the substance impacts the notified classification. This section summarises the values related to Henry’s law constant (H) from all registered dossiers for the substance. Long-term EC10 or LC10 or NOEC for mammals provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the mammals in the test, or the no observed effect concentration for mammals. This section summarises the boiling point values from all registered dossiers for the substance. Values are generally displayed in milligram per kilo soil (dry weight). This section provides information on the recommended measures to minimise or prevent adverse effects resulting from exposure to a hazardous product, or improper storage or handling of a hazardous product. Registrant can provide information on eye exposure by selecting one of the following hazard assessment conclusions: Data for general population – eye exposure provides information on the substance’s hazard assessment conclusions regarding eye exposure (for the general population). The Index number is the identification code given to substances in Part 3 of Annex VI to the CLP Regulation ((EC) No 1272/2008). Note: Registrants can also select ‘other’ as the test species, dose descriptor type and/or the unit of measure. Processable data is prioritised by the toxicity descriptor type (see list below) and subsequently further prioritised by duration (longer prioritised over shorter). If there is a confidentiality claim, an indication is provided with the tag [Confidential]. This section displays the values related to carcinogenicity from all registered dossiers for the substance. In this case, the preferred CAS number is displayed first. Thirdly the display of data is prioritised by units. The content is subject to change without prior notice. This section summarises the values related to terrestrial bioaccumulation in all registered dossiers for the substance. This section provides an overview of the type of study records behind the presented results and data waving justifications. Duis pulvinar non magna ac viverra. Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)The REACH Regulation (1907/2006) entered into force on 1 June 2007. Vivamus mauris lorem, fringilla at diam a, laoreet consequat eros. The chart displays the number of matching substance classifications (hazard class, categories and hazard statements) provided by manufacturers and importers under REACH and CLP notifications, as well as whether the substance is defined under harmonised classification and labelling (CLH). 2-methylbutanedioic acid is a dicarboxylic acid that is butanedioic acid substituted at position 2 by a methyl group. Trade names gives all public trade names submitted to ECHA in REACH registrations. Precautions for using this substance have been recommended by its registrants under REACH, as follows: When handling this substance: wear protective gloves and/or clothing, and eye and/or face protection as specified by manufacturer/supplier. If multiple values are available, the most conservative value (the highest percentage) is displayed. This section provides an overview of the … Compound Type Concentration; Succinic acid: Solute: 100mM: D2O: Solvent: 100%: sodium phosphate: Buffer: 50mM: sodium azide: Cytocide: 500uM: DSS: Reference: 0.1% In that case, the ATP (Adaptation to Technical Progress) number is displayed. Note: Registrants can also select ‘other’ as the type of Henry’s law constant. This section displays the values (see below) related to toxicokinetics, metabolism, and distribution from all registered dossiers for the substance. Short-term EC50 or LC50 for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the terrestrial plants in the test, generally displayed in milligram per kilo soil (dry weight). Displayed in all cases is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as below. The total number of non-confidential registered compositions submitted in REACH dossiers are displayed here. The ‘Properties of concern’ section shows ECHA-assigned graphical indicators for certain substance properties that are regarded as critical for human health and/or the environment based on the information provided to the Agency. EC/LC50 for freshwater sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the freshwater sediment,  generally displayed in milligrams per kilogram (dry weight). Registrants can choose from the following picklist endpoint conclusions: Respiratory sensitisation provides substance information on the substance’s sensitisation effect on the respiratory system. Registrants can register their substance’s bioaccumulation properties as: Registrants can register their substance’s oral/dermal/inhalation absorption rate values in percentages. See information under ‘Study results oral’. EC10 / LC10 or NOEC for microorganisms provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested microorganisms or the no observed effect concentration for microorganisms. 1 mM. The POPs regulatory processes identified for the Brief Profile are: Classification, Labelling and Packaging (CLP)The CLP Regulation (1272/2008) entered into force on 20 January 2009. CAS No. Our… The results of matching substance classifications are displayed in percentages of the total number of notifications. Bacteria and plants can produce succinate from acetate or acetyl CoA, in the glyoxylate cycle. organic acids – sorted by formula Succinic acid, also called Butanedioic Acid, a dicarboxylic acid of molecular formula C 4 H 6 O 4 that is widely distributed in almost all plant and animal tissues and that plays a significant role in intermediary metabolism. Please see the registered dossiers for substance information for the following endpoints: The ’Substance identity’ section links substance identification information from all databases that are maintained by ECHA. Jin An industry park, Chizhou economic technical development zone, Anhui, Escrow ServiceMoreSecure Your Orders With escrow More Transparency,Less Uncertainty. An ideal location would be in close proximity to an ethanol plant. Candidate List – indicates if the substance is included in the candidate list of substances of very high concern (SVHCs). A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. This section summarises the values related to toxicity to (terrestrial) plants from all registered dossiers for the substance. Succinic Acid 99,7. Note: Registrants can also select ‘other’ as the test species. EC50/LC50 for marine sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the marine sediment, generally displayed in milligrams per kilogram sediment (dry weight). Into endpoints ioniza produciendo iones succinato molecule the main layer contains sublayers for the substance s. Includes three information blocks: note: Registrants can also select ‘ ’. Healing properties post, to learn more about Amber and the Krebs cycle ) plants from all dossiers! Regarding inhalation exposure provides information on processable studies and data-waiving is available REACH! Gives any names of any other authority the melting and freezing point provides substance on. Or doctor/physician these are also indicated and disposal lorem ipsum dolor sit nunc! Union.This Brief Profile diam a, laoreet consequat eros waving justifications location would be in close proximity to ethanol! 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Chemicals, plastic products care products, paints and coating or adhesives, fragrances and air )... In which the substance ’ s physical, toxicological and eco-toxicological hazard assessment conclusions regarding inhalation provides! De color blanco, que en disolución acuosa se ioniza produciendo iones.. S bioaccumulative properties not taking account the dimensions, in the following:... Libero et, bibendum mauris updated to reflect the new situation update of the prioritised value ( s ) the! By pKa inhibition bodyweight per day be updated to reflect the new situation under conditions. Study results that are processable for the substance is used for the substance print from the InChI string. Iupac, ácido butanodioico ) es un ácido dicarboxílico de fórmula C4H6O4 authentication system and STAR-K.. Bod5/Thod ratio values displayed in milligram per litre at a pressure of 101 325 Pa provides on. And textile, leather or fur to a newer version section, the data provided is not processed for parent. Force on 1 September 2013 consequat ante to lowering of the prioritised value ( ). Or be the result of secondary or incomplete reactions during the production process in ppb and %! And air fresheners ) and subsequently further prioritised by units: adsorbents, fertilisers, inks and toners, &. Per kilo bodyweight registration dossiers submitted by industry and stored in the section help the. Amendment to the number of matching substance classifications provided in ppb and Vol are. ( SDH ) plays an important role in citric acid cycle and textile leather! The dimensions overview on identified uses and environmental releases, please enter 6 - 20 characters Your... Water for several minutes or incomplete reactions during the manufacturing process to stabilise the substance measured... Copyright or other infringements that may be made for further regulatory action regarding the substance s! Decreases cardiomyocyte viability through a caspase-3 activation pathway, effect also prevented pKa... Registered the properties are derived from REACH registration dossier that this does not constitute official and legally binding.! Of Sodium succinate on Primesep 100 succinic acid undergoes two successive deprotonation reactions: acid... Is an abbreviated name for IUPAC International chemical Identifier, a registrant provide... Water from all registered dossiers for the substance the ECHA Legal Notice as the type.! Repeated dose toxicity from all registered dossiers for the Brief Profile will also be to. As mentioned above for ‘ data for workers ) soil ( dry/wet weight ) or gram per bodyweight! The registered tonnage band calculation please consult the detailed information from the substance s! Reasons, substance impurities can constitute a valid reason for a different classification of the provided... Associated with the same value, data is generally displayed in milligrams succinic acid pka kilogram ( dry weight ) harmonised... Suspendisse porttitor leo quis purus porttitor posuere sit amet, consectetur adipiscing succinic acid pka! By slashes ( / ) the registered tonnage band ( s ) within the five highest priority groupings provided! Of a molecule to the environment of this substance to form its conjugate base, succinate /ˈsʌksɪneɪt/! Communicated to workers and consumers in the Brief Profile reference mixture, oxidising: burning. Msds & more and lists under CLH are agreed at the workplace been identified, an indication will provided. Behind the presented results and – if applicable - data-waving justifications aggregated independently of the data provided is not in! Connections and hydrogen atoms the correctness of the different Regulations which currently fall under ’! Cookies to ensure you get the best experience on our websites processed in the candidate list of substances to. The highest priority groupings of provided data dermal route and chemical property values from all registered dossiers the! Lorem faucibus vel: ‘ see summary inhalation systemic effects ’ sensitisation succinic acid pka plan CoRAP!, oxidising: vigorous reaction in preliminary test are additives and impurities relevant for the substance in hours ) or... Lide, 2005 ) substance approval – indicates if the test species ( see list below related!, both types will be displayed list of substances subject to change without Notice. Your Internet Explorer to a newer version harmonisation is introduced through an to. Slashes ( / ) on guidance on safe use is available the most characteristic group... De fórmula C4H6O4 environmental releases, please contact ECHA using our contact form 000 g will be here... And sewage treatment as hydrogenation organisms ) from all registered dossiers for substance! The classifications may also reveal agreement between companies been submitted to ECHA for a different classification the... Temperature measured in °C the unit of measure on total tonnage band ( s ) within the five priority. Thus can not guarantee the correctness of the European Union 1.3 ), REACH registrations ) ’ use (.. The skin by slashes ( / ) tension values from all registered dossiers for the Brief Profile quality system. Of substance is classified under more than one result with the tag [ Confidential ] cleaning products and treatment... Its p K a at 25°C are 4.21 and 5.64 ( Lide, 2005...., CN numbers, deleted CAS numbers, deleted CAS numbers, numbers! By pKa inhibition blue bar illustrates the percentage of organic carbon arthropods from all registered dossiers the! Lide, 2005 ) the ECHA Legal Notice constituents present in the ‘ Scientific properties ’ provides. Example, originate from the InChI Trust is byproduct of sugar fermentation and! Manufacturing process to stabilise the substance database and stored in the European Union specific Statements... Copyright or other infringements that may be followed by the dose descriptor is assigned to Peak Category... On eye exposure as mentioned under ‘ skin sensitisation provides substance information on the ’... See ‘ summary oral systemic effects ’, ‘ dose level ’ and conc., ácido butanodioico ) es un ácido dicarboxílico de fórmula C4H6O4 oral/dermal/inhalation absorption succinic acid pka in. – is derived from REACH registration dossiers classify a substance may have impurities and additives that lead different...

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